Cannabis

I have found it very helpful in almost all aspects of ME. The trick, I found, was to not get high. I first noticed the effect when I was younger and a smoker. I didn't enjoy the feeling of being high, but after 30-40 min or so, the high would recede and I would feel generally better in the following ways: • Less inflammation • Clear thinking (no brain fog) • More energetic • Less ache and pain • No pressure in head

I could go on. I suspect it's the immunosuppressant activity, but can't be sure. I got my doctor to prescribe a synthetic oral analogue of THC and found it to be extremely helpful. It had the added benefit of not really giving a high. Similar to eating marijuana rather than smoking it. I would honestly recommend talking to your doctor about Nabilone (Cesamet) or Dronabinol (Marinol). After 30 years with this disease, this is the only therapy of significant all-round benefit for me.

Seems like I may be an outlier here, but for me THC is good for energy/masking symptoms, but the next 1-2 days I feel much worse than if I had skipped it. Not worth it for me. CBD I’m neutral on, but for me THC seem harmful.

This study explored the safety and tolerability of a CBD-dominant cannabis-based medicinal product for treating long COVID symptoms. It involved 12 participants who used MediCabilis 5% CBD Oil daily for 21 weeks, followed by a 3-week period without the drug, with data collected through self-reports and wearable technology.

The study found that the CBD product was safe and well-tolerated, with no serious adverse events reported. However, the research design had limitations, particularly in recruitment strategy, and the study lacked a control group, which limits conclusions about the treatment's effectiveness.

For individuals with long COVID, this study suggests that CBD-based treatments might be safe to use and could be worth exploring further. However, it does not provide strong evidence of effectiveness, so patients should consult healthcare providers before considering this option.

This was a small-scale clinical trial published in a reputable journal, but its lack of a control group and small sample size limit the reliability of its findings. Larger, more rigorous studies are needed to confirm the results.

This study explored the effects of a combined plant extract (CPE) formulation, which included Cannabis sativa among other plants, on individuals with long COVID. It was a randomized, double-blinded, placebo-controlled trial conducted in Thailand, where participants received either the CPE supplement or a placebo for 7 days.

The study found that while the CPE supplement did not significantly reduce inflammation markers like C-reactive protein (CRP), it did lower the total symptom score and reduced moderate to severe symptoms such as fatigue and post-exertional malaise (PEM). Health-related quality of life scores did not show significant differences, and adverse events were mild and resolved quickly.

For individuals with long COVID, this study suggests that the CPE supplement, including Cannabis sativa, may help alleviate certain severe symptoms like fatigue and PEM. However, it does not appear to improve overall inflammation or quality of life significantly.

This study is fairly reliable as it is a randomized controlled trial, which is considered a high standard in clinical research. However, the small sample size and the need for validation of the symptom questionnaire limit its generalizability.